Project P-18 Viral

This ancillary study of HPV and HSV-1 and -2 infection as part of the P18 Cohort Study of racially/ethnically and socioeconomically diverse YMSM seek to (1) to detect cases of oral and anal HPV infection through site-specific PCR testing and clinically significant HPV subtype through serotyping and to estimate HPV persistence and clearance rates; (2) to identify uptake and completion of HPV vaccination via a combination of self-reported vaccination history in addition to New York State HPV vaccine registry verification; (3) to determine the prevalence and incidence of HSV-1 and HSV-2 by serology;  (4)  to  estimate HIV risk among YMSM with and without HSV-1 and/or HSV-2 and to assess whether HSV infection explains racial/ethnic disparities in HIV risk; and (5) to determine the extent to which biological, behavioral, psychosocial and social/structural factors explain the likelihood of (a) oral/anal HPV infection, broadly and infection of HPV 6, 11, 16, and 18, specifically; (b) HPV vaccination uptake, (c) HSV-1 and HSV-2 infection, and (d) co-infections of HIV, HSV, and/or HPV.

Funder: National Institute of Allergy and Infectious Disease/National institutes of Health