Using Multiphase Optimization Strategy to Optimize Cost-effective, Sustainable and Scalable Smoking Cessation Package for HIV Care

The adverse health impact of cigarette smoking on persons living with HIV is profound and effective treatments for long-term abstinence remain elusive. There is an acute need for interventions that address barriers to quitting and clinical barriers to effectively treating a broad heterogeneous population of people living with HIV (PLWH) who smoke cigarettes. This study’s long-term goal is to improve health outcomes among PLWH who smoke by providing optimized smoking cessation interventions that could be implemented in HIV care settings. This proposal will test four intervention components aimed at barriers to quitting among PLWH who smoke: motivational interviewing counseling, peer mentoring, text-messaging and combination nicotine replacement therapy (nicotine patch plus nicotine lozenge). These components have shown promise in research but are under-utilized to help PLWH quit. The ultimate objective of the study is to select the smoking cessation package that constitutes a cost-effective, sustainable smoking cessation package that can be implemented in HIV care.