The Center for Health Data Science leverages data in combination with knowledge across disciplines and places, with the ultimate goal of addressing quality of life and other public health priorities. CHDS enhances interdisciplinary public health research, teaching and practice through leveraging and developing data science methods in conjunction with public health knowledge, frameworks and action as well as with other disciplines such as computer science, urban planning and sociology. CHDS values and promotes pluralistic knowledge discovery and action, such as through cross-border student and faculty exchanges based on long-term relationships, and by working directly with practitioners on the ground to help address community needs.