Using Multiphase Optimization Strategy (MOST) to Optimize a Cost-effective, Sustainable and Scalable Smoking Cessation Package for Smokers in HIV Clinical Care

The major goal of this proposal is to optimize a smoking cessation treatment package for people with HIV (PWH) that can be integrated into existing HIV care in the southern African region.  We will employ an efficient full factorial design to evaluate four evidence-based smoking cessation interventions for their efficacy in this population – both independently and in combination – as well as their implementability and scalability potential in the region.